Myosarcomas of the small and large intestine: A clinicopathologic study
- 1 September 1983
- journal article
- research article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 24 (1), 67-72
- https://doi.org/10.1002/jso.2930240116
Abstract
A retrospective study was made of 38 myosarcomas of the small and large intestines (34 leiomyosarcomas and 4 malignant leiomyoblastomas). Endoenteric, small, and noninvasive tumors were successfully treated by simple wedge excision, cautery snare removal, or segmental bowel resection with a high 5-yr cure rate of 86% (12/14). Exo-enteric tumors often invaded adjacent structures or perforated into the peritoneal cavity. Extensive resection procedures, including pancreaticoduodenectomy, abdominoperineal resection, and pelvic exenteration salvaged only 13% (2/16) of these patients. Three clinicopathologic factors adversely affected prognosis: i(tumor size greater than 5 cm in diameter, ii) extra-intestinal invasion or free perforation, and iii high histopathologic grade of malignancy. The presence of none, one, two, or three of these adverse factors gave decreasing 5-yr survival rates of 100, 44, 31, and 0%, respectively. These observations suggest use of a multimodal treatment program that may minimize treatment failure from local as well as distant disease.Keywords
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