One-Dimensional Haemodynamic Modeling and Wave Dynamics in the Entire Adult Circulation
- 2 April 2015
- journal article
- Published by Springer Science and Business Media LLC in Annals of Biomedical Engineering
- Vol. 43 (6), 1443-1460
- https://doi.org/10.1007/s10439-015-1313-8
Abstract
One-dimensional (1D) modeling is a powerful tool for studying haemodynamics; however, a comprehensive 1D model representing the entire cardiovascular system is lacking. We present a model that accounts for wave propagation in anatomically realistic systemic (including coronary and cerebral) arterial/venous networks, pulmonary arterial/venous networks and portal veins. A lumped parameter (0D) heart model represents cardiac function via a time-varying elastance and source resistance, and accounts for mechanical interactions between heart chambers mediated via pericardial constraint, the atrioventricular septum and atrioventricular plane motion. A non-linear windkessel-like 0D model represents microvascular beds, while specialized 0D models are employed for the hepatic and coronary beds. Model-derived pressure and flow waveforms throughout the circulation are shown to reproduce the characteristic features of published human waveforms. Moreover, wave intensity profiles closely resemble available in vivo profiles. Forward and backward wave intensity is quantified and compared along major arteriovenous paths, providing insights into wave dynamics in all of the major physiological networks. Interactions between cardiac function/mechanics and vascular waves are investigated. The model will be an important resource for studying the mechanics underlying pressure/flow waveforms throughout the circulation, along with global interactions between the heart and vessels under normal and pathological conditions.Keywords
This publication has 135 references indexed in Scilit:
- Altered coronary vascular control during cold stress in healthy older adultsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2012
- A pulse wave propagation model to support decision-making in vascular access planning in the clinicMedical Engineering & Physics, 2011
- Pulse wave propagation in a model human arterial network: Assessment of 1-D visco-elastic simulations against in vitro measurementsJournal of Biomechanics, 2011
- Mechanisms of myocardium-coronary vessel interactionAmerican Journal of Physiology-Heart and Circulatory Physiology, 2010
- Numerical Validation of a New Method to Assess Aortic Pulse Wave Velocity from a Single Recording of a Brachial Artery Waveform with an Occluding CuffAnnals of Biomedical Engineering, 2010
- Three-Wall Segment (TriSeg) Model Describing Mechanics and Hemodynamics of Ventricular InteractionAnnals of Biomedical Engineering, 2009
- Wave-energy patterns in carotid, brachial, and radial arteries: a noninvasive approach using wave-intensity analysisAmerican Journal of Physiology-Heart and Circulatory Physiology, 2005
- Age-related changes in left and right ventricular filling velocity profiles and their relationship in normal subjectsAmerican Heart Journal, 1993
- Doppler predictions of pulmonary artery pressure, flow, and resistance in adultsAmerican Heart Journal, 1987
- Evaluation of blood flow velocity in the ascending aorta and main pulmonary artery of normal subjects by Doppler echocardiographyAmerican Heart Journal, 1984