Toxicological approaches to complex mixtures.
Open Access
- 1 December 1993
- journal article
- review article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 101 (suppl 4), 155-165
- https://doi.org/10.1289/ehp.93101s4155
Abstract
This paper reviews the role of toxicological studies in understanding the health effects of environmental exposures to mixtures. The approach taken is to review mixtures that have received the greatest emphasis from toxicology; major mixtures research programs; the toxicologist's view of mixtures and approaches to their study; and the complementary roles of toxicological, clinical, and epidemiological studies. Studies of tobacco smoke, engine exhaust, combustion products, and air pollutants comprise most of the past research on mixtures. Because of their great experimental control over subjects, exposures, and endpoints, toxicologists tend to consider a wider range of toxic interactions among mixture components and sequential exposures than is practical for human studies. The three fundamental experimental approaches used by toxicologists are integrative (studying the mixture as a whole), dissective (dissecting a mixture to determine causative constituents), and synthetic (studying interactions between agents in simple combinations). Toxicology provides information on potential hazards, mechanisms by which mixture constituents interact to cause effects, and exposure dose-effect relationships; but extrapolation from laboratory data to quantitative human health risks is problematic. Toxicological, clinical, and epidemiological approaches are complementary but are seldom coordinated. Fostering synergistic interactions among the disciplines in studying the risks from mixtures could be advantageous.Keywords
This publication has 48 references indexed in Scilit:
- Effects of repeated inhalation exposures to 1‐nitropyrene, benzo[a]pyrene, Ga2O3particles, and SO2alone and in combinations on particle clearance, bronchoalveolar lavage fluid composition, and histopathologyJournal of Toxicology and Environmental Health, 1989
- Lung retention and binding of [14c]‐1‐nitropyrene when inhaledby f344 rats as a pure aerosol or adsorbed to carbon black particlesJournal of Toxicology and Environmental Health, 1989
- Health effects of acid aerosols formed by atmospheric mixtures.Environmental Health Perspectives, 1989
- Tumours of the respiratory tract in rats and hamsters following chronic inhalation of engine exhaust emissionsJournal of Applied Toxicology, 1989
- Effect of repeated exposures to nitrogen dioxide and sulfuric acid mist alone or in combination on mucociliary clearance from the lungs of rabbitsEnvironmental Research, 1987
- Effects of intermittent inhalation exposures to mixed atmospheres of NO2and H2SO4on rabbit alveolar macrophagesJournal of Toxicology and Environmental Health, 1987
- Synergistic interaction between nitrogen dioxide and respirable aerosols of sulfuric acid or sodium chloride on rat lungsToxicology and Applied Pharmacology, 1987
- Chronic effects on the respiratory tract of hamsters, mice and rats after long‐term inhalation of high concentrations of filtered and unfiltered diesel engine emissionsJournal of Applied Toxicology, 1986
- Identification of DNA damage as a result of exposure of rats of diesel engine exhaustCarcinogenesis: Integrative Cancer Research, 1986
- GC/MS and MS/MS studies of diesel exhaust mutagenicity and emissions from chemically-defined fuelsEnvironmental Science & Technology, 1984