A train of symptoms, coupled with retardation of tissue metabolism and with inactivity of the reproductive glands, not only accompanies states of experimentally induced hypophysial deficiency, but is equally characteristic of clinical states of hypopituitarism. The more notable of these symptoms are a tendency, in the chronic cases, toward an unusual deposition of fat, a lowering of body temperature, slowing of pulse and respiration, fall in blood pressure, and oftentimes a pronounced somnolence.