Effects of Surface Hydrophilicity and Microtopography on Early Stages of Soft and Hard Tissue Integration at Non‐Submerged Titanium Implants: An Immunohistochemical Study in Dogs
- 1 November 2007
- journal article
- Published by Wiley in The Journal of Periodontology
- Vol. 78 (11), 2171-2184
- https://doi.org/10.1902/jop.2007.070157
Abstract
The aim of the present study was to investigate the effects of surface hydrophilicity and microtopography on soft and hard tissue integration at non-submerged titanium implants. Implantation of conventional sand-blasted large grit and acid-etched (SLA) and chemically modified SLA (modSLA) titanium implants with differently structured transmucosal surfaces (SLA implants: machined [M-SLA] or SLA [SLA-SLA]; modSLA implants: mod acid-etched [modA] [modA-modSLA] or modSLA [modSLA-modSLA]) was performed bilaterally in the upper and lower jaws of 15 beagle dogs. The animals were sacrificed after 1, 4, 7, 14, or 28 days. Tissue reactions were assessed histomorphometrically and immunohistochemically using monoclonal antibodies to transglutaminase II (angiogenesis) and osteocalcin. Although the junctional epithelium commonly was separated from M-SLA and SLA-SLA implants by a gap, the epithelial cells appeared to be in close contact with modA-modSLA surfaces after 14 days of healing. Moreover, modA-modSLA and modSLA-modSLA groups showed a well-vascularized subepithelial connective tissue exhibiting collagen fibers that started to extend and attach partially perpendicular to the implant surface. The highest and statistically significant mean bone-to-implant contact areas were observed in the modA-modSLA and modSLA-modSLA groups at days 7, 14, and 28. Within the limits of this study, it may be concluded that soft and hard tissue integration was influenced mainly by surface hydrophilicity rather than by microtopography.Keywords
This publication has 38 references indexed in Scilit:
- Soft tissue reactions to plaque formation at implant abutments with different surface topographyJournal of Clinical Periodontology, 2002
- The mucosal attachment at different abutmentsJournal of Clinical Periodontology, 1998
- The interface between the mucosa and the implantPeriodontology 2000, 1998
- Comparison of surface roughness of oral hard materials to the threshold surface roughness for bacterial plaque retention: A review of the literatureDental Materials, 1997
- The Effect of Surface Roughness on Early In Vivo Plaque Colonization on TitaniumThe Journal of Periodontology, 1997
- The peri‐implant hard and soft tissues at different implant systems. A comparative study in the dog.Clinical Oral Implants Research, 1996
- An in vivo Study of the Influence of the Surface Roughness of Implants on the Microbiology of Supra- and Subgingival PlaqueJournal of Dental Research, 1993
- The role of connective tissue in inhibiting epithelial downgrowth on titanium‐coated percutaneous implantsJournal of Biomedical Materials Research, 1992
- Effects of a grooved titanium‐coated implant surface on epithelial cell behavior in vitro and in vivoJournal of Biomedical Materials Research, 1989
- The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfacesJournal of Maxillofacial Surgery, 1981