Aspirin, Heparin, and Fibrinolytic Therapy in Suspected Acute Myocardial Infarction
- 20 March 1997
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 336 (12), 847-860
- https://doi.org/10.1056/nejm199703203361207
Abstract
In this article, we review the randomized clinical trials of aspirin, of heparin, and of fibrinolytic therapy in patients with suspected acute myocardial infarction to determine which of these treatments have been shown to improve survival and other major clinical outcomes.AspirinBenefits of Aspirin during and after Suspected Myocardial InfarctionThe Second International Study of Infarct Survival (ISIS-2) demonstrated conclusively the substantial value of aspirin therapy in patients with suspected acute myocardial infarction1 (and other studies have shown the value of aspirin in patients with unstable angina2). In the ISIS-2 trial, assignment to one month of treatment with . . .Keywords
This publication has 81 references indexed in Scilit:
- Overview of randomized trials of intravenous heparin in patients with acute myocardial infarction treated with thrombolytic therapyThe American Journal of Cardiology, 1996
- A pooled analysis of coronary arterial patency and left ventricular function after intravenous thrombolysis for acute myocardial infarctionThe American Journal of Cardiology, 1994
- ISIS-3 and GISSI-2: No survival advantage with tissue plasminogen activator over streptokinase, but a significant excess of strokes with tissue plasminogen activator in both trialsThe American Journal of Cardiology, 1993
- Comparison of intravenous urokinase plus heparin versus heparin alone in acute myocardial infarctionThe American Journal of Cardiology, 1991
- Principles and practice of coronary thrombolysis and conjunctive treatmentThe American Journal of Cardiology, 1991
- Heparin as an adjunctive treatment after thrombolytic therapy for acute myocardial infarctionThe American Journal of Cardiology, 1991
- Usefulness of antithrombotic therapy in resting angina pectoris or non-Q-wave myocardial infarction in preventing death and myocardial infarction (a pilot study from the antithrombotic therapy in acute coronary syndromes study group)The American Journal of Cardiology, 1990
- Prehospital thrombolysis in acute myocardial infarctionThe American Journal of Cardiology, 1990
- Aspirin, Heparin, or Both to Treat Acute Unstable AnginaNew England Journal of Medicine, 1988
- A Prospective Trial of Intravenous Streptokinase in Acute Myocardial Infarction (I.S.A.M.)New England Journal of Medicine, 1986