Secondary acute lymphoblastic leukaemia is constitutional and probably not related to prior therapy
- 30 March 2015
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 170 (1), 50-55
- https://doi.org/10.1111/bjh.13386
Abstract
Very little is known about secondary acute lymphoblastic leukaemia (s-ALL). This retrospective analysis studied a cohort of s-ALL patients treated at a single centre between 1994 and 2013, while comparing therapy-associated ALL (t-ALL) and antecedent malignancy ALL (am-ALL) patients. Thirty-two patients with s-ALL were identified. The overall incidence was 94% among ALL adults while T-cell s-ALL was rare (12% of s-ALLs). The median time interval between two malignant diagnoses was 53years (range: 01-28). In contrast to previous reports, most of the s-ALLs were CD10+ and without KMT2A (MLL) abnormalities. The overall survival (OS) rates of the entire cohort at 12 and 24months from ALL diagnosis was 49% and 25%, respectively. Most patients (n=23, 72%) received prior chemo-/radio-therapy for their first malignancy (t-ALL) and only 9 (28%) did not (am-ALL). No significant difference was found in the incidence of B-/T- lineage ALL, extramedullary disease, blood count, and the rate of Philadelphia-positive ALL, nor in the rates of complete remission (P=055) and OS (P=097). This similarity, together with high incidence of family malignancy in both groups, raise the possibility that s-ALL patients may have an inherent predisposition to malignancies and a history of previous therapy may be of lesser importance in the pathogenesis of s-ALL.Keywords
This publication has 25 references indexed in Scilit:
- Treatment of adults with acute lymphoblastic leukemia: Do the specifics of the regimen matter?Cancer, 2012
- Therapy-Related Acute Lymphoblastic Leukemia Without 11q23 AbnormalityAmerican Journal of Clinical Pathology, 2010
- Four Cases of Hematologic Malignancy Following Radioactive Iodine Therapy for Thyroid CancerAnnals of Laboratory Medicine, 2008
- Biologic features and treatment outcome of secondary acute lymphoblastic leukemia—a review of 101 casesAnnals Of Oncology, 2008
- Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non‐Hodgkin's lymphoma: The ESCALE study (SFCE)International Journal of Cancer, 2007
- Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993Blood, 2005
- High frequency of pro-B acute lymphoblastic leukemia in adults with secondary leukemia with 11q23 abnormalitiesLeukemia, 2003
- Acute leukemia following a previous malignancy: do acute lymphoid leukemia and acute myeloid leukemia have common risk factors?The Hematology Journal, 2000
- Chronic myeloid leukaemia following 131I treatment for thyroid carcinoma: a report of two cases and review of the literatureClinical Endocrinology, 1995