Assessment of atherosclerosis: the role of flow-mediated dilatation
Open Access
- 23 September 2010
- journal article
- review article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 31 (23), 2854-2861
- https://doi.org/10.1093/eurheartj/ehq340
Abstract
Evidence suggests that endothelial dysfunction is on the causal pathway for both atherogenesis and destabilization of established plaques. In this review, the role of flow-mediated dilatation (FMD) as a non-invasive method to assess endothelial function is discussed. Technical modifications and development of analysis software have significantly improved the variability of the method. Following a strict standardized protocol enables reproducible measurements to be achieved and export of the technique from specialized laboratories to population studies and multicentre settings. Endothelial function assessed by FMD has been shown to be affected by cardiovascular risk factors, to be related to structural arterial disease and to cardiovascular outcome, validating its use for studying the pathophysiology of arterial disease. Numerous studies have also demonstrated that it is responsive to physiological and pharmacological interventions. Flow-mediated dilatation provides unique opportunities in drug development programmes to assess an early rapidly responsive signal of risk or benefit, complementing endpoints of structural arterial disease and cardiovascular outcomes that take much longer and are more expensive.Keywords
This publication has 94 references indexed in Scilit:
- Predictive Value of Brachial Flow-Mediated Dilation for Incident Cardiovascular Events in a Population-Based StudyCell Metabolism, 2009
- Coenzyme Q10 Improves Endothelial Dysfunction in Statin-Treated Type 2 Diabetic PatientsDiabetes Care, 2009
- Comparison of Effects of Rosuvastatin (10 mg) Versus Atorvastatin (40 mg) on Rho Kinase Activity in Caucasian Men With a Previous Atherosclerotic EventThe American Journal of Cardiology, 2008
- Angiotensin-Converting Enzyme Inhibition Improves Vascular Function in Rheumatoid ArthritisCirculation, 2008
- Simvastatin Improves Flow-Mediated Dilation but Reduces Adiponectin Levels and Insulin Sensitivity in Hypercholesterolemic PatientsDiabetes Care, 2008
- Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy IndividualsExperimental Diabetes Research, 2008
- Predictive Value of Reactive Hyperemia for Cardiovascular Events in Patients With Peripheral Arterial Disease Undergoing Vascular SurgeryArteriosclerosis, Thrombosis, and Vascular Biology, 2007
- Endothelial Dysfunction in Childhood InfectionCirculation, 2005
- Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary ArteriesNew England Journal of Medicine, 1986
- The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineNature, 1980