Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System
Open Access
- 1 January 2012
- journal article
- research article
- Published by Hindawi Limited in International Journal of Biomedical Imaging
- Vol. 2012, 1-11
- https://doi.org/10.1155/2012/509783
Abstract
The blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clinical applications. Optical microangiography (OMAG) is a method for obtaining three-dimensional images of blood vessels within a volume of tissue. In this study we propose to quantify OMAG images obtained with a spectral domain optical coherence tomography system. A technique for determining three measureable parameters (the fractal dimension, the vessel length fraction, and the vessel area density) is proposed and validated. Finally, the repeatability for acquiring OMAG images is determined, and a new method for analyzing small areas from these images is proposed.Keywords
Funding Information
- National Institutes of Health (R01HL093140, R01HL093140S, R01EB009682, R01DC01201, 0855733G)
This publication has 38 references indexed in Scilit:
- Cellular and 3D optical coherence tomography assessment during the initiation and progression of retinal degeneration in the Ccl2/Cx3cr1-deficient mouseExperimental Eye Research, 2011
- In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomographyBiomedical Optics Express, 2011
- Highly sensitive imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiographyBiomedical Optics Express, 2011
- In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiographyLasers in Surgery and Medicine, 2011
- Scaling rules for diffusive drug delivery in tumor and normal tissuesProceedings of the National Academy of Sciences, 2011
- Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retinaJournal of Biomedical Optics, 2011
- Optical microangiography provides an ability to monitor responses of cerebral microcirculation to hypoxia and hyperoxia in miceJournal of Biomedical Optics, 2011
- Signal attenuation and box-counting fractal analysis of optical coherence tomography images of arterial tissueBiomedical Optics Express, 2010
- The Hallmarks of CancerCell, 2000
- Functional architecture of cortex revealed by optical imaging of intrinsic signalsNature, 1986