Prostaglandins: Localization in Subcellular Particles of Rat Cerebral Cortex
- 8 September 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 157 (3793), 1187-1189
- https://doi.org/10.1126/science.157.3793.1187
Abstract
Homogenates of rat cerebral cortex contain material corresponding to prostaglandins E1, E2, F1α, and F2α which are concentrated mainly in the light microsomal and mitochondrial fractions. Only the former fraction exhibits significant ability to synthesize prostaglandins E1 and F1α from bis-homo-γ-linolenic acid. After subfractionation of the crude mitochondrial fraction, prostaglandin E and F material is found mainly in the cholinergic and noncholinergic nerve endings. We conclude that the nerve endings are a storage site, whereas the light microsomes are the site of synthesis.This publication has 12 references indexed in Scilit:
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