Grading Errors in Prostatic Needle Biopsies: Relation to the Accuracy of Tumor Grade in Predicting Pelvic Lymph Node Metastases
- 1 May 1982
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 127 (5), 919-922
- https://doi.org/10.1016/s0022-5347(17)54132-4
Abstract
To examine how accurately needle biopsies reflect the true histologic grade of prostatic cancers the histologic grade of needle biopsy specimens was compared to that of the radical prostatectomy specimen in 66 consecutive patients. Needle biopsies were given a lower grade than the prostatectomy specimen in 21 patients (33%) and a higher grade in 5 patients (8%). To examine how accurately the tumor grade of needle biopsy specimens predicts lymph node metastases in patients with clinical stage B prostatic cancer, the needle biopsy grade was compared to lymph node metastases in 78 consecutive patients who underwent staging pelvic lymphadenectomy. Of the patients, 13% with well differentiated cancer, 50% with moderately differentiated cancer and 64% with poorly differentiated cancer had pelvic lymph node metastases. In most cases grading errors did not influence the capacity of needle biopsies to predict nodal involvement. Apparently, although prostatic needle biopsies are associated with significant errors in grading they do provide valuable information about the predominant histologic pattern, which reflects the biologic potential of the tumor.This publication has 6 references indexed in Scilit:
- Nodal Involvement as A Prognostic Indicator in Patients with Prostatic CarcinomaJournal of Urology, 1980
- Experience with Gleason’s Histopathologic Grading in Prostatic CancerJournal of Urology, 1980
- The value of perineal punch biopsy in estimating the histological grade of carcinoma of the prostateThe Prostate, 1980
- Pelvic Lymphadenectomy for Staging Prostatic Carcinoma: Is it Always Necessary?Journal of Urology, 1979
- The Impact of Current Staging Procedures in Assessing Disease Extent of Prostatic AdenocarcinomaJournal of Urology, 1979
- Unsuspected carcinoma of the prostate in suprapubic prostatectomy specimens.A clinicopathological study of 55 consecutive casesCancer, 1960