Unveiling an abundant core microbiota in the human adult colon by a phylogroup-independent searching approach
- 26 August 2010
- journal article
- Published by Oxford University Press (OUP) in The ISME Journal
- Vol. 5 (3), 519-531
- https://doi.org/10.1038/ismej.2010.129
Abstract
The potential presence of widespread and stable bacterial core phylogroups in the human colon has promoted considerable attention. Despite major efforts, no such phylogroups have yet been identified. Therefore, using a novel phylogroup- and tree-independent approach, we present a reanalysis of 1 114 722 V2 region and 71 550 near full-length 16S rRNA sequences from a total of 210 human beings, with widespread geographic origin, ethnic background and diet, in addition to a wide range of other mammals. We found two highly prevalent core phylogroups (cores 1 and 2), belonging to the clostridial family Lachnospiraceae. These core phylogroups showed a log-normal distribution among human individuals, while non-core phylogroups showed more skewed distributions towards individuals with low levels compared with the log-normal distribution. Molecular clock analyses suggest that core 2 co-evolved with the radiation of vertebrates, while core 1 co-evolved with the mammals. Taken together, the stability, prevalence and potential functionality support the fact that the identified core phylogroups are pivotal in maintaining gut homeostasis and health.Keywords
This publication has 55 references indexed in Scilit:
- Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twinsProceedings of the National Academy of Sciences, 2010
- Characterizing a model human gut microbiota composed of members of its two dominant bacterial phylaProceedings of the National Academy of Sciences, 2009
- A core gut microbiome in obese and lean twinsNature, 2008
- Symbiotic gut microbes modulate human metabolic phenotypesProceedings of the National Academy of Sciences, 2008
- The Human Microbiome ProjectNature, 2007
- Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseasesProceedings of the National Academy of Sciences, 2007
- Human gut microbes associated with obesityNature, 2006
- An obesity-associated gut microbiome with increased capacity for energy harvestNature, 2006
- Genome sequence of the Brown Norway rat yields insights into mammalian evolutionNature, 2004
- The Host Genotype Affects the Bacterial Community in the Human Gastronintestinal TractMicrobial Ecology in Health & Disease, 2001