On the Specificity of Choline Esterase in Nervous Tissue

Abstract
The esterase present in various nerve tissues, on which the role of acetylcholine in the mechanism of nervous action was studied, was demonstrated to be a specific enzyme. It differed essentially from the esterases present in other tissues or serum. The enzyme from all nerve sources was unable to split carbaminoylcholine or benzoylcholine. It split butyrylcholine and acetyl-[beta]-methylcholine at a lower rate than acetylcholine.