T cells that encounter virus in the complete absence of a particular H-2 antigen are nonresponsive when stimulated again in the context of that H-2 antigen.
Open Access
- 1 January 1980
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 151 (1), 166-173
- https://doi.org/10.1084/jem.151.1.166
Abstract
Immunologically naive BALB/c (H-2d) and C57BL/6J (B6) (H-2b) T[thymus-derived]-cell populations can, after filtration to remove alloreactive precursor lymphocytes, be induced to respond to vaccinia virus presented in the context of H-2Kk when stimulated in an appropriate recipient. Exposure to vaccinia virus 6 wk previously completely abrogated the capacity of BALB/c T cells to interact with H-2Kk-vaccinia virus. This is true for negatively selected B6 thoracic duct lymphocytes taken at 14 or 18 days but not 6 wk after immunization; the discrepancy may reflect the progressive emergence of new T cells in the latter group. No evidence could be found for the operation of suppression. T cells that interact with virus in the absence of the relevant H-2 antigen may be tolerized. Whereas stimulation to effector function is H-2 restricted, induction of immune paralysis may be unrestricted. The capacity of T cell populations to respond to virus presented in the context of allogeneic H-2 determinants depends upon previous antigenic experience.Keywords
This publication has 19 references indexed in Scilit:
- T-cell inhibition of humoral responsivenessCellular Immunology, 1978
- T-cell populations specifically depleted of alloreactive potential cannot be induced to lyse H-2-different virus-infected target cells.The Journal of Experimental Medicine, 1978
- Chemiluminescence of phagocytic cells caused by N-formylmethionyl peptidesThe Journal of Experimental Medicine, 1978
- Structural Differences between Parent and Mutant H-2K Glycoproteins from Two H-2K Gene Mutants: B6.C-H-2ba (Hzl) and B6-H-2bd (M505)The Journal of Immunology, 1977
- Two Different VH Gene Products Make Up the T‐Cell ReceptorsScandinavian Journal of Immunology, 1976
- Regulation by the H-2 gene complex of macrophage-lymphoid cell interactions in secondary antibody responses in vitro.The Journal of Experimental Medicine, 1976
- Regulation of the T-cell response to ectromelia virus infection. I. Feedback suppression by effector T cells.The Journal of Experimental Medicine, 1976
- Specificity of Virus‐Immune Effector T Cells for H‐2K or H‐2D Compatible Interactions: Implications for H‐Antigen DiversityImmunological Reviews, 1976
- H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. The H-2K structure involved is coded by a single cistron defined by H-2Kb mutant mice.The Journal of Experimental Medicine, 1976
- A Theory of Self-Nonself DiscriminationScience, 1970