Humoral Regulation of Erythropoiesis VII. Shortened Survival of Erythrocytes Produced by Erythropoietine or Severe Anemia

Abstract

Red cells formed in response to erythropoietine or severe anemia have a substantially shortened life span. The possibility is proposed that this is related to the macrocytic character of the cells. The results are in agreement with the hypothesis that erythropoietine is not the sole regulator of red cell production.