Polymeric Growth Factor Delivery Strategies for Tissue Engineering
Open Access
- 1 January 2003
- journal article
- review article
- Published by Springer Science and Business Media LLC in Pharmaceutical Research
- Vol. 20 (8), 1103-1112
- https://doi.org/10.1023/a:1025034925152
Abstract
Purpose. Tissue engineering seeks to replace and regrow damaged or diseased tissues and organs from either cells resident in the surrounding tissue or cells transplanted to the tissue site. The purpose of this review is to present the application of polymeric delivery systems for growth factor delivery in tissue engineering. Methods. Growth factors direct the phenotype of both differentiated and stem cells, and methods used to deliver these molecules include the development of systems to deliver the protein itself, genes encoding the factor, or cells secreting the factor. Results. Results in animal models and clinical trials indicate that these approaches may be successfully used to promote the regeneration of numerous tissue types. Conclusions. Controlling the dose, location, and duration of these factors through polymeric delivery strategies will dictate their utility in tissue regeneration.Keywords
This publication has 80 references indexed in Scilit:
- Use of Recombinant Human Bone Morphogenetic Protein-2 to Achieve Posterolateral Lumbar Spine Fusion in HumansSpine, 2002
- Intravascular adenoviral agents in cancer patients: Lessons from clinical trialsCancer Gene Therapy, 2002
- Synergistic enhancement of bone formation and healing by stem cell–expressed VEGF and bone morphogenetic protein-4JCI Insight, 2002
- Bone consolidation is enhanced by rhBMP‐2 in a rabbit model of distraction osteogenesisJournal of Orthopaedic Research, 2002
- Bone Morphogenetic Protein-Transduced Human Fibroblasts Convert to Osteoblasts and Form Bonein VivoTissue Engineering, 2002
- Therapeutic Potential of Implanted Tissue‐Engineered Bioartificial Muscles Delivering Recombinant Proteins to the Sheep HeartAnnals of the New York Academy of Sciences, 2002
- Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcersExpert Opinion on Biological Therapy, 2002
- TRANSFER OF PLATELET-DERIVED GROWTH FACTOR-BB GENE BY GENE GUN INCREASES CONTRACTION OF COLLAGEN LATTICE BY FIBROBLASTS IN DIABETIC AND NON-DIABETIC HUMAN SKINScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, 2000
- Osteoinductive ProteinsAnnals of Medicine, 1993
- Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-βScience, 1987