THE INFLUENCE OF VARIOUS PHYSIOLOGICAL SUBSTANCES ON THE GLYCOGENOLYSIS OF SURVIVING RAT LIVER1

Abstract

Rat liver glycogenolysis as it normally occurs in surviving tissue slices suspended in a buffered salt soln. was shown to be inhibited to a considerable extent by large doses of insulin added in vitro (up to 43% at 4 U. per cc). Because of this finding and results reported in literature, the essential action of insulin on the liver is believed to be an inhibition of the glyco-genolytic process, particularly when the latter is proceeding at a high rate.