Some Binding-Related Drug Properties are Dependent on Thermodynamic Signature
Open Access
- 17 December 2010
- journal article
- Published by Wiley in Chemical Biology & Drug Design
- Vol. 77 (3), 161-165
- https://doi.org/10.1111/j.1747-0285.2010.01075.x
Abstract
No abstract availableKeywords
This publication has 27 references indexed in Scilit:
- A Thermodynamic Approach to the Affinity Optimization of Drug CandidatesChemical Biology & Drug Design, 2009
- Binding of Small-Molecule Ligands to Proteins: “What You See” Is Not Always “What You Get”Structure, 2009
- Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120Structure, 2008
- Do enthalpy and entropy distinguish first in class from best in class?Drug Discovery Today, 2008
- Thermodynamic and Structure Guided Design of Statin Based Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A ReductaseJournal of Medicinal Chemistry, 2008
- Reaching for high-hanging fruit in drug discovery at protein–protein interfacesNature, 2007
- Small-molecule inhibitors of protein–protein interactions: progressing towards the dreamNature Reviews Drug Discovery, 2004
- Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.Current Protein & Peptide Science, 2004
- HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sitesNature, 2002
- Energetics of the HIV gp120-CD4 binding reactionProceedings of the National Academy of Sciences, 2000