Syndromes with gingival fibromatosis: A systematic review
- 1 May 2021
- journal article
- review article
- Published by Wiley in Oral Diseases
- Vol. 27 (4), 881-893
- https://doi.org/10.1111/odi.13369
Abstract
Objective The aim of systematic review was to describe the phenotypes and molecular profiles of syndromes with gingival fibromatosis (GF). Methods A comprehensive search of PubMed, LILACS, Livivo, Scopus, and Web of Science was conducted using key terms relevant to the research questions and supplemented by a gray literature search. The Methodological Quality and Synthesis of Case Series and Case Reports in association with the Case Series and Prevalence Studies from the Joanna Briggs Institute critical appraisal tools were used for the risk of bias. We followed the PRISMA checklist guidelines. Results Eighty-four studies reporting GF as an oral manifestation of a syndrome were identified in this review. Enamel renal syndrome was the most frequently reported syndrome with GF, represented by 54 individuals in 19 studies, followed by Zimmermann-Laband syndrome with 24 individuals in 15 studies and Costello syndrome, which was presented in a case series study with 41 individuals. Among reported cases, other clinical manifestations such as hypertrichosis, ectopic gingival calcification, and cherubism were described. Conclusions The results emphasize the need of systematic oro-dental-facial phenotyping for future descriptions as well as further molecular analysis in order to better understand the occurrence of syndromic GF.Keywords
This publication has 106 references indexed in Scilit:
- Autosomal recessive gingival hyperplasia and dental anomalies caused by a 29-base pair duplication in the FAM20A geneJournal of Human Genetics, 2013
- FAM20A Mutations Can Cause Enamel-Renal Syndrome (ERS)PLoS Genetics, 2013
- Gingival fibromatosis with multiple unusual findings: report of a rare caseInternational Journal of Oral Science, 2012
- Hereditary gingival fibromatosisJournal of Indian Society of Periodontology, 2012
- Whole-Exome Sequencing Identifies FAM20A Mutations as a Cause of Amelogenesis Imperfecta and Gingival Hyperplasia SyndromeAmerican Journal of Human Genetics, 2011
- Oral and dental abnormalities in Barber-Say syndromeAmerican Journal of Medical Genetics Part A, 2010
- An international registry of systematic-review protocolsThe Lancet, 2010
- Gingival fibromatosis and Klippel-Trénaunay-Weber syndromeOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 1995
- Hereditary gingival fibromatosis associated with growth hormone deficiencyBritish Journal of Oral and Maxillofacial Surgery, 1990
- Gingival Fibromatosis, Hypertelorism, Anti‐Mongoloid Obliquity, Multiple Telangiectases and Cafe Au Lait Pigmentation; A Unique Combination of Developmental AnomaliesThe Journal of Periodontology, 1973