Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.
- 1 November 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (11), 4927-4931
- https://doi.org/10.1073/pnas.74.11.4927
Abstract
The endogenous central nervous tissue substance called MLC (morphine-like compound) [beef brain human urine] bound to the opiate receptors of the mouse neuroblastoma .times. glioma [rat] hybrid cell line NG108-15. The interaction of MLC with these opiate receptors was noncooperative, as was the interaction of morphine, naloxone and Leu-enkephalin with these receptors. A specific antibody to morphine will bind MLC but will not bind .beta.-endorphin, Leu-enkephalin, or Met-enkephalin. MLC may be a different type of endogenous ligand for the opiate receptor.This publication has 16 references indexed in Scilit:
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