Coagulase in Reversing Antibacterial Activity of Normal Human Serum on Micrococcus pyogenes.

Abstract

By following the growth of coagulase positive, virulent and coagulase negative, avirulent, strains of M. pyogenes in undiluted normal human serum for periods of 24 hours the coagulase positive strains grew very well while the coagulase negative strains were completely inhibited in their growth. By treating actively bacteriostatic human serum with partially purified preparations of cell free coagulase, coagulase negative strains which were susceptible to serum bacteriostasis were able to grow.