Interferon and Murine Leukemia. I. Inhibitory Effect of Interferon Preparations on Development of Friend Leukemia in Mice.

Abstract

Administration of concentrated preparations of interferon of high titer (extracted from either mouse brain or serum and spleen) inhibited the development of splenomegaly induced by Friend virus in Swiss and DBA2 mice. Interferon was effective only when treatment was continued daily throughout the duration of the experiment, and when inoculated intra-peritoneally (rather than intravenously).