Age and gender specific cut-off values to improve the performance of d-dimer assays to predict the risk of venous thromboembolism recurrence
- 17 May 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Internal and Emergency Medicine
- Vol. 8 (3), 229-236
- https://doi.org/10.1007/s11739-011-0608-5
Abstract
The Prolong study shows that continuing vitamin K antagonists (VKA) in patients with abnormal D-dimer (evaluated by a qualitative assay, Clearview Simplify D-dimer) results in a significant reduction of venous thromboembolism (VTE) recurrence. The present study retrospectively analyzes a subgroup of patients enrolled in the Prolong study with a view to calculate cut-off values for six quantitative D-dimer methods to predict the risk of VTE recurrence. We measured D-dimer levels by VIDAS D-dimer Exclusion (bioMerieux), STA Liatest D-dimer (DiagnosticaStago), HemosIL D-dimer and HemosIL D-dimer HS (Instrumentation Laboratory), Innovance D-dimer (Siemens) and AutoDimer (Trinity Biotech) in frozen plasma aliquots sampled 30 ± 10 days after VKA cessation in 390 patients enrolled in the Prolong study. During follow-up (562.7 years), 28 patients had recurrent VTE (7.2%, 5.0% person-years). Since D-dimer levels are positively correlated with age and significantly lower in men, we calculated method-specific cut-off values according to age and gender. The HRs for VTE recurrence calculated using method-specific cut-off values based on age and gender are higher than those using cut-off values indicated by the manufacturers for VTE exclusion in symptomatic outpatients. These data suggest that method-specific cut-off values calculated according to patient age and gender can be more accurate in identifying patients at a higher risk for VTE recurrence. These method-specific cut-off values are being evaluated in the ongoing prospective management multicenter DULCIS study.Keywords
This publication has 16 references indexed in Scilit:
- Elevated d-dimer levels predict recurrence in patients with idiopathic venous thromboembolism: a meta-analysisJournal of Thrombosis and Haemostasis, 2009
- Systematic Review: d-Dimer to Predict Recurrent Disease after Stopping Anticoagulant Therapy for Unprovoked Venous ThromboembolismAnnals of Internal Medicine, 2008
- Antithrombotic Therapy for Venous Thromboembolic DiseaseChest, 2008
- Unprovoked recurrent venous thrombosis: prediction by D‐dimer and clinical risk factorsJournal of Thrombosis and Haemostasis, 2008
- Combination of D‐dimer, F1+2 and residual vein obstruction as predictors of VTE recurrence in patients with first VTE episode after OAT withdrawalJournal of Thrombosis and Haemostasis, 2008
- D‐dimer concentration increases with age reducing the clinical value of the D‐dimer assay in the elderlyInternal Medicine Journal, 2007
- Diurnal, Seasonal, and Blood-Processing Patterns in Levels of Circulating Fibrinogen, Fibrin D-Dimer, C-Reactive Protein, Tissue Plasminogen Activator, and von Willebrand Factor in a 45-Year-Old PopulationCell Metabolism, 2007
- D-Dimer Levels and Risk of Recurrent Venous ThromboembolismJAMA, 2003
- Risk of Venous Thromboembolism Recurrence: High Negative Predictive Value of D-dimer Performed after Oral Anticoagulation Is StoppedThrombosis and Haemostasis, 2002
- Fibrin Degeneration Product Concentrations (D-Dimers) in the Course of AgeingGerontology, 1995