Abstract
The relationship between high-density lipoproteins (HDL) and atherosclerotic coronary artery disease is examined from an epidemiological viewpoint. Lipid, cholesterol, triglyceride and lecithin-cholesterol acyltransferase metabolism is reviewed with respect to atheroma formation. Lowered plasma HDL-cholesterol levels are reported in patients with coronary heart disease. Therapeutic intervention based on HDL-cholesterol levels is recommended only after a review of elevated very low-density lipoprotein (VLDL) and low-density lipoprotein.