Changes in magnetic resonance imaging before and after autologous stem cell transplantation correlate with response and survival in multiple myeloma
- 11 June 2012
- journal article
- clinical trial
- Published by Ferrata Storti Foundation (Haematologica) in Haematologica
- Vol. 97 (11), 1757-1760
- https://doi.org/10.3324/haematol.2012.065359
Abstract
In multiple myeloma, focal lesions, as well as diffuse and variegated infiltration patterns, can be detected by magnetic resonance imaging. In the current study, we compared treatment response in 100 myeloma patients with changes in infiltration patterns in whole body magnetic resonance imaging before and after autologous stem cell transplantation. We found an agreement between serological response and changes in imaging (PP=0.004) as well as for focal (P=0.01) infiltration patterns. The number of focal lesions at second magnetic resonance imaging was of prognostic significance for overall survival (P=0.001). We conclude that treatment response in myeloma goes along with a decrease in imaging findings. We suggest that residual disease after high-dose chemotherapy detected by magnetic resonance imaging increases the risk of relapse. Therefore, myeloma patients with such findings after treatment might benefit from further cytoreduction.Keywords
This publication has 22 references indexed in Scilit:
- Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17pBlood, 2012
- Magnetic Resonance Imaging in Multiple Myeloma: Diagnostic and Clinical ImplicationsJournal of Clinical Oncology, 2007
- A prospective comparison of 18F-fluorodeoxyglucose positron emission tomography-computed tomography, magnetic resonance imaging and whole-body planar radiographs in the assessment of bone disease in newly diagnosed multiple myelomaHaematologica, 2007
- International uniform response criteria for multiple myelomaLeukemia, 2006
- Whole-body MRI in the detection of bone marrow infiltration in patients with plasma cell neoplasms in comparison to the radiological skeletal surveyEuropean Radiology, 2006
- Prognostic significance of magnetic resonance imaging of bone marrow in previously untreated patients with multiple myelomaAnnals Of Oncology, 2005
- Dynamic contrast‐enhanced MRI for assessing the disease activity of multiple myeloma: A comparative study with histology and clinical markersJournal of Magnetic Resonance Imaging, 2005
- Prognostic value of vertebral lesions detected by magnetic resonance imaging in patients with stage I multiple myelomaBritish Journal of Haematology, 1999
- Stage III multiple myeloma: clinical and prognostic value of spinal bone marrow MR imaging.Radiology, 1998
- Magnetic resonance imaging patterns in patients with multiple myelomaBritish Journal of Haematology, 1997