Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
- 21 March 2013
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 31 (1), 675-704
- https://doi.org/10.1146/annurev-immunol-032712-095946
Abstract
Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell development, differentiation, and function. Mammals have eight PI3K catalytic subunits that are divided into three classes based on similarities in structure and function. Specific roles for the class I PI3Ks have been broadly investigated and are relatively well understood, as is the function of their corresponding phosphatases. More recently, specific roles for the class II and class III PI3Ks have emerged. Through vertebrate evolution and in parallel with the evolution of adaptive immunity, there has been a dramatic increase not only in the genes for PI3K subunits but also in genes for phosphatases that act on 3-phosphoinositides and in 3-phosphoinositide-binding proteins. Our understanding of the PI3Ks in immunity is guided by fundamental discoveries made in simpler model organisms as well as by appreciating new adaptations of this signaling module in mammals in general and in immune cells in particular.Keywords
This publication has 156 references indexed in Scilit:
- mTOR Signaling in Growth Control and DiseaseCell, 2012
- Autophagy in the control and pathogenesis of viral infectionCurrent Opinion in Virology, 2011
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1Cell, 2011
- Structural Effects of Oncogenic PI3Kα MutationsPublished by Springer Science and Business Media LLC ,2010
- Oncogenic Mutations of PIK3CA in Human CancersPublished by Springer Science and Business Media LLC ,2010
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino AcidsCell, 2010
- PI3 Kinase Signals BCR-Dependent Mature B Cell SurvivalCell, 2009
- Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K SignalingCancer Cell, 2009
- AKT/PKB Signaling: Navigating DownstreamCell, 2007
- A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin SignalingCell, 2006