Molecular mechanisms of cisplatin resistance in cervical cancer
Open Access
- 1 June 2016
- journal article
- review article
- Published by Informa UK Limited in Drug Design, Development and Therapy
- Vol. 10, 1885-1895
- https://doi.org/10.2147/dddt.s106412
Abstract
Patients with advanced or recurrent cervical cancer have poor prognosis, and their 1-year survival is only 10%–20%. Chemotherapy is considered as the standard treatment for patients with advanced or recurrent cervical cancer, and cisplatin appears to treat the disease effectively. However, resistance to cisplatin may develop, thus substantially compromising the efficacy of cisplatin to treat advanced or recurrent cervical cancer. In this article, we systematically review the recent literature and summarize the recent advances in our understanding of the molecular mechanisms underlying cisplatin resistance in cervical cancer.Keywords
This publication has 103 references indexed in Scilit:
- Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cellsScientific Reports, 2013
- Sensitization of Cervical Cancer Cells to Cisplatin by Genistein: The Role of NFB and Akt/mTOR Signaling PathwaysJournal of Oncology, 2012
- Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiologyPharmacology & Therapeutics, 2011
- Autophagic pathways as new targets for cancer drug developmentActa Pharmacologica Sinica, 2010
- Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper ChelatorCancer Cell, 2010
- Paclitaxel plus oxaliplatin for recurrent or metastatic cervical cancer: A New York Cancer Consortium StudyGynecologic Oncology, 2010
- Nuclear factor-κB in cancer development and progressionNature, 2006
- Biological and chemical inhibitors of NF‐κB sensitize SiHa cells to cisplatin‐induced apoptosisMolecular Carcinogenesis, 2005
- Tumour stem cells and drug resistanceNature Reviews Cancer, 2005
- Cisplatin: mode of cytotoxic action and molecular basis of resistanceOncogene, 2003