Oxygen-Hemoglobulin Dissociation Curves: Effect of Inherited Enzyme Defects of the Red Cell
- 8 August 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 165 (3893), 601-602
- https://doi.org/10.1126/science.165.3893.601
Abstract
The blood of a patient with a deficiency of hexokinase in the red cells and a decreased concentration of 2, 3-diphosphoglycerate in the red cells showed an increased affinity for oxygen, whereas a patient with a deficiency of pyruvate kinase and an elevated concentration of 2, 3-diphosphoglycerate in the red cells had blood with a decreased affinity for oxygen. Defects in red cell glycolysis may alter the oxygen affinity of blood by virtue of their effect on 2, 3-diphosphoglycerate concentrations in red cells.Keywords
This publication has 7 references indexed in Scilit:
- Red-Cell 2,3-Diphosphoglycerate Levels in Subjects with Chronic HypoxemiaNew England Journal of Medicine, 1969
- Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levelsJCI Insight, 1968
- Effect of organic and inorganic phosphates on the oxygen equilibrium of human erythrocytesArchives of Biochemistry and Biophysics, 1967
- Hereditary Hemolytic Anemia with Hexokinase DeficiencyNew England Journal of Medicine, 1967
- The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobinBiochemical and Biophysical Research Communications, 1967
- Electrodes for Blood pO2 and pCO2 DeterminationJournal of Applied Physiology, 1958
- A Simplified Lucite Cuvette for the Spectrophotometric Measurement of Hemoglobin and OxyhemoglobinJournal of Applied Physiology, 1958