Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome
Open Access
- 10 March 2008
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 23 (5), 1214-1219
- https://doi.org/10.1093/humrep/den065
Abstract
Polycystic ovary syndrome (PCOS) is a heterogenic, complex common genetic disease. Multiple pathways are involved in its pathogenesis, including the androgen signaling pathway and insulin signaling pathway. Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) is a putative member of the androgen receptor–chaperone–co-chaperone complex, and may play a role in androgen signaling as a co-chaperone. Polymorphisms in the SGTA gene have not been evaluated for a role in PCOS. Women with and without PCOS (287 cases, 187 controls) were genotyped for three single nucleotide polymorphisms (SNPs) in SGTA. SNPs and haplotypes were determined and tested for association with PCOS and component traits of PCOS. For SNP rs1640262, homozygotes for the minor allele were protected against PCOS (P = 0.009). Haplotype 1 (G–A–T) was associated with increased risk of PCOS (P = 0.015). In women with PCOS, haplotype 2 (A–G–C) was associated with increased insulin resistance (P = 0.013), consequently resulting in increased insulin secretion (P = 0.014). This study presents genetic evidence suggesting a potential role of SGTA in the pathogenesis of PCOS. SGTA may provide a connection between multiple pathways in PCOS.Keywords
This publication has 47 references indexed in Scilit:
- Control of Androgen Receptor Signaling in Prostate Cancer by the Cochaperone Small Glutamine–Rich Tetratricopeptide Repeat Containing Protein αCancer Research, 2007
- Human SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrestExperimental Cell Research, 2006
- Diagnosis, epidemiology, and genetics of the polycystic ovary syndromeBest Practice & Research Clinical Endocrinology & Metabolism, 2006
- Overexpression of small glutamine‐rich TPR‐containing protein promotes apoptosis in 7721 cellsFEBS Letters, 2005
- Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 2004
- The International HapMap ProjectNature, 2003
- The Cochaperone Bag-1L Enhances Androgen Receptor Action via Interaction with the NH2-Terminal Region of the ReceptorMolecular and Cellular Biology, 2003
- Determination and use of haplotypes: Ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-AmericansGenetics in Medicine, 2003
- Translational control by the 3′-UTR: the ends specify the meansTrends in Biochemical Sciences, 2003
- Allelic discrimination using fluorogenic probes and the 5′ nuclease assayGenetic Analysis: Biomolecular Engineering, 1999