Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria
- 15 April 2009
- journal article
- Published by Wiley in European Journal of Inorganic Chemistry
- Vol. 2009 (13), 1739-1745
- https://doi.org/10.1002/ejic.200801159
Abstract
A series of N-heterocyclic carbene silver complexes have been synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burkholderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assays demonstrated the exceptional efficacy of the complexes against these potentially weaponizable pathogens.Keywords
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