Impairment of the Diurnal Fibrinolytic Response in Man
- 1 June 1973
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 32 (6), 752-758
- https://doi.org/10.1161/01.res.32.6.752
Abstract
Diurnal patterns of plasma euglobulin fibrinolytic activity, estimated by the fibrin plate method, were determined in groups of young normal and older normal subjects, in subjects with type IV hyperlipoproteinemia, and in subjects with coronary artery disease who had normal lipid profiles. The marked diurnal increases in fibrinolytic activity observed in the young normal subjects were significantly reduced in a large percent of the older normal subjects and in most of the subjects with coronary artery disease or type IV hyperlipoproteinemia. Although not conclusive, these findings were compatible with the hypothesis that an impairment in the responsiveness of the fibrinolytic system may be related to the development of coronary artery disease.Keywords
This publication has 16 references indexed in Scilit:
- Lipid and carbohydrate abnormalities in patients with angiographically documented coronary artery diseaseThe American Journal of Cardiology, 1969
- Enhancement of the Fibrinolytic Activity by Venous Occlusion in Patients with Primary ‘Carbohydrate-Induced’ HypertriglyceridemiaActa Haematologica, 1969
- Effect of age, sex, and diurnal variation on the human fibrinolytic systemJournal of Clinical Pathology, 1967
- Fibrinolysis Related to Age in MenBritish Journal of Haematology, 1963
- Lipids, Blood Coagulation, and FibrinolysisAnnual Review of Medicine, 1963
- Variation in Fibrinolytic Activity After Acute Myocardial Infarction and After the Administration of Oral Anticoagulant Drugs and Intravenous HeparinBritish Journal of Haematology, 1960
- STUDIES ON THE THROMBOLYTIC ACTIVITY OF HUMAN PLASMA *JCI Insight, 1960
- FIBRINOLYSIS IN MYOCARDIAL INFARCTIONHeart, 1958
- THE BIOLOGICAL SIGNIFICANCE OF FIBRINOLYSISThe Lancet, 1956