Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells.
- 1 March 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 74 (3), 1229-1233
- https://doi.org/10.1073/pnas.74.3.1229
Abstract
Mouse spleen cells cocultured with irradiated allogeneic stimulator cells develop cytolytic effector cells capable of lysing 51Cr-labeled syngeneic trinitrophenyl-derivatized tumor or spleen targets and to a lesser degree unconjugated tumor cells in addition to the allogeneic stimulator cells. Lysis of trinitrophenyl-syngeneic targets was inhibited competitively by cold trinitrophenyl-syngeneic tumor or spleen targets as well as by cells bearing the allogeneic stimulator H-2 haplotype demonstrating the immunological specificity of the interaction. Allogeneic H-2 specificities may be considered variants of modified autologous H-2 specificities against which cytolytic thymus-derived clones potentially exist that are capable of exerting immunological surveillance.This publication has 14 references indexed in Scilit:
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