Histamine in food: is there anything to worry about?
Open Access
- 20 March 2007
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 35 (2), 349-352
- https://doi.org/10.1042/bst0350349
Abstract
Biogenic mono-, di- and poly-amines are widely distributed among living organisms. The amines fulfil many important functions in the human body both in the periphery and brain. Some authors suggest that foods rich in biogenic amines, especially histamine, present high health hazards for consumers. However, this is conditional on a range of other factors. The alimentary tract is well equipped with enzymes that inactivate amines and the blood–brain barrier prevents them entering the brain from the circulation. Oxidative deamination, methylation, acetylation and transglutamylation are the degradation pathways which operate efficiently in the stomach, intestines and liver. Particularly important is oxidative deamination. Food histamine poisoning or cheese reaction, manifested itself in patients treated with drugs that inhibit amine oxidases or in patients showing an enterocytic diamine oxidase deficit. It is rather food allergy, which should worry us more, as endogenous histamine release from mast cells is more dangerous. Preventive measures should be undertaken against increases in food allergies.Keywords
This publication has 46 references indexed in Scilit:
- 5-HTBritish Journal of Pharmacology, 2006
- Histamine inactivation in the colon of pigs in relationship to abundance of catabolic enzymesScandinavian Journal of Gastroenterology, 2006
- Food hypersensitivity—immunologic (peripheral) or cognitive (central) sensitisation?Psychoneuroendocrinology, 2005
- Anti‐ulcer drugs promote IgE formation toward dietary antigens in adult patientsThe FASEB Journal, 2005
- Polyamines biosynthesis and oxidation in free-living amoebaeAmino Acids, 2004
- Intolerance to dietary biogenic amines: a reviewAnnals of Allergy, Asthma & Immunology, 2003
- Boosted systemic immune and local responsiveness after intestinal inflammation in orally sensitized guinea pigsGastroenterology, 1995
- Human intestinal diamine oxidase (DAO) activity in Crohn's disease: A new marker for disease assessment?Inflammation Research, 1990
- Serum Antibodies to Cow's Milk Proteins in Pediatric Inflammatory Bowel Disease.Acta Paediatrica, 1989
- Histamine and its metabolism in mammals part II: Catabolism of histamine and histamine liberationInflammation Research, 1975