Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts
Open Access
- 12 January 2011
- journal article
- research article
- Published by Wiley in Evidence-Based Complementary and Alternative Medicine
- Vol. 2011 (1), 1-7
- https://doi.org/10.1093/ecam/nep111
Abstract
To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, 16 Bangladeshi medicinal plants were successively extracted with n-hexane, dichloromethane, methanol and water. The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer-cell lines (gastric: AGS; colon: HT-29; and breast: MDA-MB-435S) using the MTT assay. Two methanolic extracts (Hygrophila auriculata and Hibiscus tiliaceous) and one aqueous extract (Limnophila indica) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against breast cancer cells (IC50 1.1–1.6 mg mL−1). Seven methanolic extracts from L. indica, Clerodendron inerme, Cynometra ramiflora, Xylocarpus moluccensis, Argemone mexicana, Ammannia baccifera and Acrostichum aureum and four aqueous extracts from Hygrophila auriculata, Bruguiera gymnorrhiza, X. moluccensis and Aegiceras corniculatum showed low toxicity (IC50 > 2.5 mg mL−1) against mouse fibroblasts but selective cytotoxicity (IC50 0.2–2.3 mg mL−1) against different cancer cell lines. The methanolic extract of Blumea lacera showed the highest cytotoxicity (IC50 0.01–0.08 mg mL−1) against all tested cell lines among all extracts tested in this study. For some of the plants their traditional use as anticancer treatments correlates with the cytotoxic results, whereas for others so far unknown cytotoxic activities were identified.Funding Information
- Griffith University
This publication has 41 references indexed in Scilit:
- Triterpenoids from the Mangrove Plant Hibiscus tiliaceusHelvetica Chimica Acta, 2008
- eCAM: An Emerging Linkage with Ethnopharmacology?Evidence-Based Complementary and Alternative Medicine, 2008
- Cytoprotective Activity ofGlycyrrhizae radixExtract against Arsenite-Induced CytotoxicityEvidence-Based Complementary and Alternative Medicine, 2008
- Endothelial cytoprotection from oxidized LDL by some crude melanesian plant extracts is not related to their antioxidant capacityJournal of Biochemical and Molecular Toxicology, 2007
- Natural Products as Sources of New Drugs over the Last 25 YearsJournal of Natural Products, 2007
- Flavonoids from Limnophila indicaPhytochemistry, 2007
- Regulatory T Cells, a Potent Immunoregulatory Target for CAM Researchers: Modulating Tumor Immunity, Autoimmunity and Alloreactive Immunity (III)Evidence-Based Complementary and Alternative Medicine, 2006
- Inhibitory Effects of Bangladeshi Medicinal Plant Extracts on Interactions between Transcription Factors and Target DNA SequencesEvidence-Based Complementary and Alternative Medicine, 2000
- Stem Cells and CAMEvidence-Based Complementary and Alternative Medicine, 2000
- The role of mitochondrial calcium transport during inflammation and the effect of anti-inflammatory drugsBiochemical Medicine and Metabolic Biology, 1986