Isolated fetal echogenic intracardiac foci or golf balls: is karyotyping for Down's syndrome indicated?
- 1 December 1999
- journal article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 106 (12), 1294-1297
- https://doi.org/10.1111/j.1471-0528.1999.tb08184.x
Abstract
To determine the prevalence of isolated echogenic intracardiac foci and the subsequent risk for Down's syndrome at 18-23 weeks in an unselected obstetric population. Prospective study. A district general hospital serving a routine obstetric population. 16,917 pregnant women who underwent a routine ultrasound screening at 18-23 weeks of gestation between November 1994 and August 1998. All women were offered screening for Down's syndrome by nuchal translucency or maternal serum biochemistry. The prevalence of isolated echogenic intracardiac foci was determined and the relative risk for Down's syndrome was calculated for different ultrasound findings. The combined sensitivity of age, nuchal translucency and maternal serum biochemistry for Down's syndrome was 84% (27/32). The relative risk for Down's syndrome was 0.17 (95% CI 0.07-0.41) for the women with normal scan findings at 18-23 weeks. The prevalence of isolated echogenic intracardiac foci at 18-23 weeks was 0.9% (144/16,917). None of these pregnancies were affected by Down's syndrome. The significance of the association between isolated echogenic intracardiac foci and Down's syndrome is a matter of ongoing debate. The data of this study suggest that in an unselected obstetric population with prior, effective, routine Down's syndrome screening, the association between isolated echogenic intracardiac foci and Down's syndrome is no longer significant.Keywords
This publication has 18 references indexed in Scilit:
- The significance of choroid plexus cysts, echogenic heart foci and renal pyelectasis in the first trimesterUltrasound in Obstetrics & Gynecology, 1998
- Significance of echogenic foci in the fetal heartUltrasound in Obstetrics & Gynecology, 1998
- Prevalence of fetal left ventricular hyperechogenic foci in a low risk populationBJOG: An International Journal of Obstetrics and Gynaecology, 1996
- Prospective evaluation of the antenatal incidence and postnatal significance of the fetal echogenic cardiac focus: A case-control studyAmerican Journal of Obstetrics and Gynecology, 1996
- The significance of echogenic foci in the fetal heart: a prospective study of 228 casesUltrasound in Obstetrics & Gynecology, 1996
- Echogenic foci in the fetal heart: a marker of chromosomal abnormalityBJOG: An International Journal of Obstetrics and Gynaecology, 1995
- Natural history of echogenic foci within ventricles of the fetal heartUltrasound in Obstetrics & Gynecology, 1995
- Second‐trimester maternal serum screening using alpha‐fetoprotein, human chorionic gonadotrophin, and unconjugated oestriol: Experience of a regional programmePrenatal Diagnosis, 1994
- Small hyperechoic ventricle: a benign foci of the fetal cardiac sonographic finding?Ultrasound in Obstetrics & Gynecology, 1994
- Ultrasonographically detectable markers of fetal chromosomal abnormalitiesThe Lancet, 1992