Antioxidant activity and components of a traditional chinese medicine formula consisting of Crataegus pinnatifida and Salvia miltiorrhiza
Open Access
- 10 May 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Complementary and Alternative Medicine
- Vol. 13 (1), 99-6
- https://doi.org/10.1186/1472-6882-13-99
Abstract
Background The aims of this study were to evaluate the antioxidant activity and to identify the antioxidant components of a traditional Chinese medicine formula consisting of a combination of Shanzha (the fruit of Crataegus pinnatifida Bge. var. major N.E.Br., SZ) and Danshen (the root of Salvia miltiorrhiza Bge., DS). This medicine is extensively used to treat cardiovascular disease. Methods Twelve samples extracted and fractionated from SZ, DS and the formula (SZ+DS) were analyzed. The concentrations of eight phenolic compounds were determined by high performance liquid chromatography. Oxygen radical absorbance capacity (ORAC) assay and 1,1-diphenyl-2-picrylhydrazyl assay were conducted to explore the antioxidant activities of the samples and of the 15 phenolic compounds detected. Correlation analysis of the antioxidant activity of herb samples and their phenolic components was performed. Results The main phenolic component in all SZ+DS samples was salvianolic acid B, which exhibited strong antioxidant activity (ORAC value: 16.73 ± 2.53, IC50 value: 8.80 ± 0.06 μM) compared with the other phenolic compounds. For all samples, there was a positive relationship between their total phenolic components and their antioxidant activities. Conclusions Phenolic compounds were the bioactive components of the herb samples, and salvianolic acid B was identified as the main bioactive compound in the SZ+DS formula.Keywords
This publication has 108 references indexed in Scilit:
- Expressing and Amplifying Positive Emotions Facilitate Goal Attainment in Workplace InteractionsFrontiers in Psychology, 2013
- Don't hide your happiness! Positive emotion dissociation, social connectedness, and psychological functioning.Journal of Personality and Social Psychology, 2011
- Relationship between Smiling and Laughter in Humans (Homo sapiens): Testing the Power Asymmetry HypothesisFolia Primatologica, 2008
- Antioxidant Activity of 45 Chinese Herbs and the Relationship with their TCM CharacteristicsEvidence-Based Complementary and Alternative Medicine, 2008
- Standardized Methods for the Determination of Antioxidant Capacity and Phenolics in Foods and Dietary SupplementsJournal of Agricultural and Food Chemistry, 2005
- Emotional Labor and Burnout: Comparing Two Perspectives of “People Work”Journal of Vocational Behavior, 2002
- Emotion at Work: To What Extent are We Expressing, Suppressing, or Faking It?European Journal of Work and Organizational Psychology, 1999
- Social Sharing of Emotion: New Evidence and New QuestionsEuropean Review of Social Psychology, 1998
- Effects of indoor lighting (illuminance and spectral distribution) on the performance of cognitive tasks and interpersonal behaviors: The potential mediating role of positive affectMotivation and Emotion, 1992
- The influence of positive affect and visual access on the discovery of integrative solutions in bilateral negotiationOrganizational Behavior and Human Decision Processes, 1986