Effect of Antiidiotypic Antibodies to HLA on Graft Survival in Renal-Allograft Recipients
- 4 June 1987
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 316 (23), 1450-1455
- https://doi.org/10.1056/nejm198706043162305
Abstract
Although the presence in the recipient of preformed antibodies to HLA antigens in the kidney of a renal-transplant donor may be associated with early graft failure, such grafts are often well tolerated. We have investigated the possibility that anti-anti-HLA (antiidiotypic) antibodies influence the outcome of renal transplantation in recipients with a history of presensitization to their donor's HLA antigens. A retrospective analysis of 20 such cases showed that in 10 patients the transplanted kidney was rejected within one month, whereas in the remaining 10 the graft was tolerated for more than a year. Nine of the 10 patients in whom the graft was tolerated had anti-anti-HLA antibodies at the time of transplantation. Nine of the 10 patients in whom the graft was rejected had antibodies that potentiated, rather than blocked, the cytotoxic activity of anti-donor-HLA antibodies.This publication has 17 references indexed in Scilit:
- Idiotypic Manipulation of the Immune Response to Transplantation AntigensImmunological Reviews, 1986
- Outcome of renal transplantation following a positive cross-match with historical sera: The ASHI surveyHuman Immunology, 1985
- CORRELATION OF HLA MATCHING WITH KIDNEY GRAFT SURVIVAL IN PATIENTS WITH OR WITHOUT CYCLOSPORINE TREATMENTTransplantation, 1985
- POSITIVE T CELL CROSSMATCH WITH STORED RECIPIENT SERA IN CADAVERIC RENAL TRANSPLANTATIONTransplantation, 1985
- SUCCESSFUL CADAVER KIDNEY TRANSPLANTATION IN PATIENTS HIGHLY SENSITIZED BY BLOOD TRANSFUSIONSTransplantation, 1985
- CADAVER RENAL TRANSPLANTATION IGNORING PEAKREACTIVE SERA IN PATIENTS WITH MARKEDLY DECREASING PRETRANSPLANT SENSITIZATIONTransplantation, 1984
- SUCCESSFUL KIDNEY TRANSPLANTATION WITH CURRENT-SERA-NEGATIVE/HISTORICAL-SERA-POSTIVE T CELL CROSSMATCHTransplantation, 1984
- KIDNEY PRESERVATION FAILURE USING COMBINED COLLINS' SOLUTION AND PLASMA PERFUSIONTransplantation, 1983
- SUCCESSFUL RENAL TRANSPLANTATION IN PATIENTS WITH T-CELL REACTIVITY TO DONORThe Lancet, 1982
- Idiotype-like determinants on human T lymphocytes alloactivated in mixed lymphocyte culture.The Journal of Experimental Medicine, 1982