Contact Surface Models for Infectious Diseases
- 1 June 2005
- journal article
- Published by Informa UK Limited in Journal of the American Statistical Association
- Vol. 100 (470), 370-379
- https://doi.org/10.1198/016214504000001754
Abstract
Controlling of infectious diseases requires information about the rates at which individuals make contact. We propose a novel approach to modeling contact rates via a continuous contact surface. This provides a more realistic and flexible representation of contact rates than currently used methods. Our approach allows modeling of sources of heterogeneity due to age, individual effects, and gender. The models are fitted to serologic survey data by maximum likelihood. This involves solving an integral equation linking the contact surface to the infection hazards. The method is illustrated with two datasets, on mumps and rubella and on Epstein–Barr virus and herpes simplex virus type 1 infection. The advantages and shortcomings of the method, particularly the identifiability of the contact surface, are discussed.Keywords
This publication has 12 references indexed in Scilit:
- The Dynamics of Herpesvirus and Polyomavirus Reactivation and Shedding in Healthy Adults: A 14‐Month Longitudinal StudyThe Journal of Infectious Diseases, 2003
- Sero‐epidemiological patterns of epstein‐barr and herpes simplex (HSV‐1 and HSV‐2) viruses in England and WalesJournal of Medical Virology, 2002
- Estimation of measles reproduction ratios and prospects for elimination of measles by vaccination in some Western European countriesEpidemiology and Infection, 2001
- Subclinical reactivation of herpes simplex virus type 1 in the oral cavityOral Microbiology and Immunology, 2000
- Directly transmitted infections modeling considering an age-structured contact rateMathematical and Computer Modelling, 1999
- Who mixes with whom? A method to determine the contact patterns of adults that may lead to the spread of airborne infectionsProceedings Of The Royal Society B-Biological Sciences, 1997
- A model-based design of a vaccination strategy against rubella in a non-immunized community of São Paulo State, BrazilEpidemiology and Infection, 1994
- Surveillance of antibody to measles, mumps, and rubella by age.BMJ, 1988
- Prolonged Oropharyngeal Excretion of Epstein–Barr Virus after Infectious MononucleosisNew England Journal of Medicine, 1973