β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF SHORTENED PEPTIDE CHAINS
- 1 February 1978
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 11 (2), 154-158
- https://doi.org/10.1111/j.1399-3011.1978.tb02834.x
Abstract
Three analogs of beta-endorphin have been synthesized by the solid-phase method: betac-endorphin-(1--5)-(28--31), betac-endorphin-(6--31) and betah-endorphin-(1--5)-(16--31). The analgesic activities of these synthetic peptides relative to that of the parent molecule are reported. All three peptides at high doses exhibit either no or much weaker analgesic activity than beta-endorphin. These data suggest that the entire beta-endorphin molecule is necessary for full in vivo analgesic activity.Keywords
This publication has 25 references indexed in Scilit:
- β-Endorphin: Lack of correlation between opiate activity and immunoreactivity by radioimmunoassayBiochemical and Biophysical Research Communications, 1977
- Isolation, characterization and opiate activity of β-endorphin from human pituitary glandsBiochemical and Biophysical Research Communications, 1976
- C fragment of lipotropin has a high affinity for brain opiate receptorsNature, 1976
- Synthesis of a nonadecapeptide corresponding to residues 37-55 of ovine prolactin. Detection and isolation of the sulfonium form of methionine-containing peptidesJournal of the American Chemical Society, 1976
- Identification of two related pentapeptides from the brain with potent opiate agonist activityNature, 1975
- Coupling of Glutamine by the Carbodiimide Method in the Solid-Phase Synthesis of two C-Terminal Peptides of SecretinBiological Chemistry, 1974
- Adrenocorticotropins. 44. Total synthesis of the human hormone by the solid-phase methodJournal of the American Chemical Society, 1973
- Use of Ilydrogen Fluoride in Merrifield Solid-Phase Peptide SynthesisJournal of the American Chemical Society, 1967
- Solid Phase Peptide Synthesis. I. The Synthesis of a TetrapeptideJournal of the American Chemical Society, 1963
- Chromatography of Proteins. I. Cellulose Ion-exchange AdsorbentsJournal of the American Chemical Society, 1956