Effects of 16S rRNA Gene Mutations on Tetracycline Resistance in Helicobacter pylori
Open Access
- 1 September 2003
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (9), 2984-2986
- https://doi.org/10.1128/aac.47.9.2984-2986.2003
Abstract
The triple-base-pair 16S rDNA mutation AGA 926-928 →TTC mediates high-level tetracycline resistance in Helicobacter pylori . In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.Keywords
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