Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.
Open Access
- 1 October 1978
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 148 (4), 871-877
- https://doi.org/10.1084/jem.148.4.871
Abstract
Purified Ly1 cells induce other T-cell sets to exert potent feedback inhibitory activity and this T-T interaction has been shown to play an important role in regulating in vivo immune responses. Approximately 2/3 of Ly1 cells also express the Qa1 surface phenotype (Ly1:Qa1+ cells). The experiments reported here indicate that Ly1:Qal+ cells are responsible for induction of feedback inhibition and that signals from both Ly1:Qal+ cells and Ly1:Qal- cells are required for optimal formation of antibody by B cells.This publication has 14 references indexed in Scilit:
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