Identification and Significance of Platelet Antibodies

Abstract

BLEEDING tendencies secondary to thrombopenia are of increasing frequency in medical, surgical and obstetric disorders. This has been attributed to diverse causes: chemotherapeutic agents^{1 , 2}; insecticides³; increased incidence of leukemia⁴; radioisotopes; cytotoxic agents in industry⁵; complete blood replacement by transfusion during pulmonary or cardiovascular surgery⁶; and the alarm reaction secondary to surgery and anesthesia.⁷ The clinical management of such thrombopenia necessitates a clear understanding of the etiologic mechanisms that produce a decrease in circulating platelets. Within recent years, it has become clear that many cases of purpura, especially idiopathic thrombocytopenic purpura and hypersplenism, are due to . . .