Suppression of adjuvant‐induced arthritis in da rats by incomplete freund's adjuvant
- 1 January 1993
- journal article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 36 (1), 126-131
- https://doi.org/10.1002/art.1780360120
Abstract
Objective. To define the effects of incomplete Freund's adjuvant (ICFA) on subsequent arthritis induced by complete Freund's adjuvant (CFA) and type II collagen (CII) in DA and Lewis rats. Methods. ICFA was injected into DA and Lewis rats before CFA or CII injection. Results. DA rats previously injected with ICFA had significantly less severe arthritis induced by CFA compared with those not receiving ICFA pretreatment (P Conclusion. The injection of ICFA alone specifically suppresses subsequent CFA‐induced arthritis in DA rats, but not in Lewis rats.Keywords
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