Proopiomelanocortin expression in the skin during induced hair growth in mice
- 1 January 1992
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 48 (1), 50-54
- https://doi.org/10.1007/bf01923606
Abstract
We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30–33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.Keywords
This publication has 11 references indexed in Scilit:
- Differential Expression and Activity of Melanogenesis-Related Proteins During Induced Hair Growth in MiceJournal of Investigative Dermatology, 1991
- Telogen skin contains an inhibitor of hair growthBritish Journal of Dermatology, 1990
- β-endorphin-like and α-MSH-like immunoreactivities in human milkLife Sciences, 1990
- Alpha-Melanocyte Stimulating Hormone Modulates Contact Hypersensitivity Responsiveness in C57/BL6 MiceJournal of Investigative Dermatology, 1989
- Hormonal Regulation of POMC Gene ExpressionAnnual Review of Physiology, 1989
- Proopiomelanocortin Gene is Expressed in Many Normal Human Tissues and in Tumors not Associated with Ectopic Adrenocorticotropin SyndromeMolecular Endocrinology, 1988
- Proopiomelanocortin Processing in the Pituitary, Central Nervous System, and Peripheral TissuesEndocrine Reviews, 1988
- The mouse genome contains two nonallelic pro-opiomelanocortin genes.Journal of Biological Chemistry, 1983
- The Distribution of Forms of Adrenocorticotropin and Endorphin in Normal, Tumorous, and Autopsy Human Anterior Pituitary Tissue: Virtual Absence of 13K Adrenocorticotropin*Journal of Clinical Endocrinology & Metabolism, 1980
- Growth of the HairPhysiological Reviews, 1954