Sequence-independent autoregulation of the adenovirus type 5 E1A transcription unit.
Open Access
- 1 November 1985
- journal article
- research article
- Published by Informa UK Limited in Molecular and Cellular Biology
- Vol. 5 (11), 3214-3221
- https://doi.org/10.1128/mcb.5.11.3214
Abstract
The adenovirus E1A gene is known to be autoregulated at the level of transcription. Autoregulation was found to be mediated by products of the E1A 13S mRNA, which induced a fivefold increase in E1A transcription rate. Deletion analysis suggested that the autoregulation did not require any specific sequence in the E1A transcriptional control region. This conclusion was reinforced by the demonstration that a cellular alpha-globin gene substituted for the E1A gene on the adenovirus chromosome was also positively regulated by E1A gene products.This publication has 51 references indexed in Scilit:
- Complete transformation by adenovirus 2 requires both E1A proteinsCell, 1984
- Functional analysis of the nucleotide sequence surrounding the cap site for adenovirus type 5 region E1A messenger RNAsJournal of Molecular Biology, 1983
- The TATA homology and the mRNA 5′ untranslated sequence are not required for expression of essential adenovirus E1A functionsCell, 1982
- Adenovirus gene expression: Control at multiple steps of mRNA biogenesisCell, 1982
- Control of messenger RNA concentration by differential cytoplasmic half-lifeJournal of Molecular Biology, 1981
- Complex splicing patterns of RNAs from the early regions of adenovirus-2Journal of Molecular Biology, 1979
- Structure of two spliced mRNAs from the transforming region of human subgroup C adenovirusesNature, 1979
- Isolation of deletion and substitution mutants of adenovirus type 5Cell, 1978
- Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5Journal of General Virology, 1977
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977