Synthesis and studies of the biological activity of novel pyrimido fused acridine derivatives
Open Access
- 1 January 2006
- journal article
- Published by National Library of Serbia in Journal of the Serbian Chemical Society
- Vol. 71 (10), 1015-1023
- https://doi.org/10.2298/jsc0610015p
Abstract
Anthranilic acid was reacted with various substituted 6-bromoquinazolinones in the presence of Cu-powder and anhydrous potassium carbonate in DMF to give acid intermediates (Ullmann Type-II condensation). All these acids were then cyclized in phosphorus oxychloride to give 11-chloropyrimido[4,5-b]acridin-4(3H)-ones. All the synthesized compounds were identified by conventional methods (1H-NMR, IR, elemental analysis) and were screened for their antimicrobial activity on some bacterial and fungal cultures. The results were compared with standard bactericides and fungicides. All the synthesized compounds exhibited moderate antibacterial and antifungal activity. .Keywords
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