Near-infrared autofluorescence for the detection of parathyroid glands
Top Cited Papers
- 1 January 2011
- journal article
- Published by SPIE-Intl Soc Optical Eng in Journal of Biomedical Optics
- Vol. 16 (6), 067012-067012-4
- https://doi.org/10.1117/1.3583571
Abstract
A major challenge in endocrine surgery is the intraoperative detection of parathyroid glands during both thyroidectomies and parathyroidectomies. Current localization techniques such as ultrasound and sestamibi scan are mostly preoperative and rely on an abnormal parathyroid for its detection. In this paper, we present near-infrared (NIR) autofluorescence as a nonintrusive, real-time, automated in vivo method for the detection of the parathyroid gland. A pilot in vivo study was conducted to assess the ability of NIR fluorescence to identify parathyroid glands during thyroid and parathyroidectomies. Fluorescence measurements at 785 nm excitation were obtained intra-operatively from the different tissues exposed in the neck region in 21 patients undergoing endocrine surgery. The fluorescence intensity of the parathyroid gland was found to be consistently greater than that of the thyroid and all other tissues in the neck of all patients. In particular, parathyroid fluorescence was two to eleven times higher than that of the thyroid tissues with peak fluorescence occurring at 820 to 830 nm. These results indicate that NIR fluorescence has the potential to be an excellent optical tool to locate parathyroid tissue during surgery.Keywords
This publication has 17 references indexed in Scilit:
- Parathyroid ImagingNeuroimaging Clinics Of North America, 2008
- Thyroid and ParathyroidPublished by Springer Science and Business Media LLC ,2007
- Complications in Thyroid and Parathyroid SurgeryPublished by Springer Science and Business Media LLC ,2007
- Image-Guided Oncologic Surgery Using Invisible Light: Completed Pre-Clinical Development for Sentinel Lymph Node MappingAnnals of Surgical Oncology, 2006
- FluorophoresPublished by Springer Science and Business Media LLC ,2006
- Investigation of near-infrared autofluorescence imaging for the detection of breast cancerIEEE Journal of Selected Topics in Quantum Electronics, 2005
- Imaging for primary hyperparathyroidism — what beginners should knowClinical Radiology, 2004
- Incidence of Inadvertent Parathyroid Removal During ThyroidectomyThe Laryngoscope, 2002
- Development of a Fiber Optic Probe to Measure NIR Raman Spectra of Cervical Tissue In VivoPhotochemistry and Photobiology, 1998
- Thresholds for Surgery and Surgical Outcomes for Patients with Primary Hyperparathyroidism: A National Survey of Endocrine SurgeonsJournal of Clinical Endocrinology & Metabolism, 1998