Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML
Open Access
- 27 July 2017
- journal article
- Published by American Society of Hematology in Blood
- Vol. 130 (4), 397-407
- https://doi.org/10.1182/blood-2017-01-763219
Abstract
Key Points Genetically accurate xenografts of CMML are achievable with near 100% frequency in NSGS mice. Robust human engraftment and overt phenotypes of CMML and JMML xenografts here facilitate preclinical therapeutic evaluation in vivo.Keywords
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