Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma
- 30 September 1980
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 287 (5783), 603-607
- https://doi.org/10.1038/287603a0
Abstract
Leader, variable (V) and joining (J) gene segments, and adjacent regions of 2 rearranged alleles of the same .kappa.-chain producing mouse myeloma, comprising approximately 3,200 base pairs, were sequenced. Sequence comparisons are reported. V-J joining in 1 of the alleles leads to a reading frame with a stop codon within the J-gene segment. Allelic exclusion is apparently realized in this tumor through the formation of such a non-functional allele.Keywords
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