Diabetic foot disease is associated with reduced erythrocyte deformability
- 28 May 2015
- journal article
- Published by Wiley in International Wound Journal
- Vol. 13 (4), 500-504
- https://doi.org/10.1111/iwj.12466
Abstract
The pathogenesis of diabetic foot disease is multifactorial and encompasses microvascular and macrovascular pathologies. Abnormal blood rheology may also play a part in its development. Using a cell flow analyser (CFA), we examined the association between erythrocyte deformability and diabetic foot disease. Erythrocytes from diabetic patients with no known microvascular complications (n = 11) and patients suffering from a diabetic foot ulcer (n = 11) were isolated and their average elongation ratio (ER) as well as the ER distribution curve were measured.Keywords
Funding Information
- Joint Research Fund of the Hebrew University and Hadassah
This publication has 20 references indexed in Scilit:
- Resuscitation With Aged Blood Exacerbates Liver Injury in a Hemorrhagic Rat Model*Critical Care Medicine, 2013
- Changes in red blood cell membrane structure in type 2 diabetes: a scanning electron and atomic force microscopy studyCardiovascular Diabetology, 2013
- Erythrocyte mechanical fragility is increased in patients with type 2 diabetesEuropean Journal of Internal Medicine, 2012
- Circulatory Risk in the Transfusion of Red Blood Cells With Impaired Flow Properties Induced by StorageTransfusion Medicine Reviews, 2011
- Microvascular dysfunction in diabetic foot disease and ulcerationDiabetes/Metabolism Research and Reviews, 2009
- Additive effect of red blood cell rigidity and adherence to endothelial cells in inducing vascular resistanceAmerican Journal of Physiology-Heart and Circulatory Physiology, 2008
- Blood banking–induced alteration of red blood cell flow propertiesTransfusion, 2007
- Blockade of Receptor for Advanced Glycation End-Products Restores Effective Wound Healing in Diabetic MiceThe American Journal of Pathology, 2001
- Erythrocyte deformability in diabetes and erythrocyte membrane lipid compositionMetabolism, 1990
- The Effect of Diabetic Control on the Width of Skeletal-Muscle Capillary Basement Membrane in Patients with Type I Diabetes MellitusNew England Journal of Medicine, 1983